BioWare CEO Ray Muzyka has confirmed that Mass Effect 3 will support Kinect.
It'll let players use voice control to converse with characters in-game, he said at Microsoft's E3 press conference just now.
You'll be able to read out dialogue from the game's conversation wheel instead of clicking on individual responses with the controller, "fluidly launch tactical assaults" against enemies by issuing voice commands to your squad mates, and also select weapons and abilities just by speaking.
Muzyka said BioWare will show more Mass Effect 3 Kinect functionality this week during E3. EA's conference is scheduled to take place later this evening.